UGT1A1-related Bilirubin Encephalopathy/Kernicterus in Adults
نویسندگان
چکیده
منابع مشابه
Bilirubin concentration, UGT1A1*28 polymorphism, and coronary artery disease.
An inverse association between serum bilirubin and cardiovascular disease has been shown in numerous retrospective and prospective studies (1–8) as well as in a metaanalysis study (9 ). Schwertner et al. (1 ) first reported that fasting serum bilirubin concentrations are inversely related to coronary artery stenosis in men. Low serum bilirubin concentrations were found to be associated with an ...
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The aim of our study was to assess the possible relationships among heme oxygenase (HMOX), bilirubin UDP-glucuronosyl transferase (UGT1A1) promoter gene variations, serum bilirubin levels, and Fabry disease (FD). The study included 56 patients with FD (M : F ratio = 0.65) and 185 healthy individuals. Complete standard laboratory and clinical work-up was performed on all subjects, together with ...
متن کاملStudies of bilirubin kinetics in normal adults.
This report describes studies of bilirubin kinetics in 13 healthy young adults. The plasma content of unconjugated bilirubin-(14)C was determined at frequent intervals for 24-30 hr after the intravenous injection of a tracer dose of unconjugated isotopic bilirubin. Fecal and urinary radioactivity were measured for 7 days. During this time cumulative recovery averaged 96% of the injected dose. T...
متن کاملAssociation of Ugt1a1 Polymorphisms and Basal Bilirubin Levels in Female Multi-racial/ethnic Cohort
Objectives: To investigate variations in UGT1A1 polymorphisms and haplotypes among African American and Caucasian women and to assess whether variants other than UGT1A1*28 are associated with total serum bilirubin levels. Methods: The (TA)n repeats and 14 single nucleotide polymorphisms (SNPs) in the UGT1A1 gene were genotyped in 335 African Americans and 181 Caucasians. Total serum bilirubin l...
متن کاملUGT1A1∗28 relationship with abnormal total bilirubin levels in chronic hepatitis C patients
Gilbert syndrome (GS) is a frequent benign clinical condition, marked by intermittent unconjugated hyperbilirubinemia, mostly due to the polymorphism uridine diphosphate-glucuronosyltransferase 1A1*28 (UGT1A1*28). Hyperbilirubinemia has been reported in a GS patient undergoing hepatitis C treatment, and other UGT isoforms polymorphisms have been linked to worse outcomes in viral hepatitis. Yet,...
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ژورنال
عنوان ژورنال: Journal of Clinical and Translational Hepatology
سال: 2021
ISSN: 2225-0719,2310-8819
DOI: 10.14218/jcth.2020.00108